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STEM CELL RESEARCH

Stem Cell Research

First, we should distinguish the difference between adult and embryonic stem cells. Embryonic stem cells are derived from an embryo and can become all types of cells within the body. They don’t have a specific function other than to be a manufacturing plant to create other types of cells. As we develop into a child these cells become more specific, called adult stem cells or multipotent stem cells.

We have many of these cells as youth, but slowly, over time, we lose them as we age. Because of this, we take longer to recover from a sports injury or a wound as quickly. Several years ago, it seemed like there was no way to turn the clock back, until now. Recent research has discovered methods in which we can turn these cells back on or take them from one part of the body and place them in another. We are currently able to take blood and prepare it in a way to concentrate the platelets and white blood cells to turn these cells on for a while to reverse or slow aging or speed up the healing cascade. There are also methods of taking your fat, which was recently discovered as a storehouse for adult stem cells, like bone marrow, where we can transfer prepared fat to other parts of the body, like the face, to slow or reverse the aging of the skin and restore lost volume.

The scientific evidence being published of late has shown we can take adult stem cells and cause them to form certain types of cells. For instance, adult stem cells from your fat can be grown into bone, cartilage, muscle and skin. This is all groundbreaking for the field of reconstructive surgery. For example, our cancer patients would get mastectomies and have their whole breast tissue removed and have implant reconstruction. They would just have a bag of skin over an implant, which would look unnatural as there’s really no fat and all you could see were the ripples and the deformities from the implant.

A Genetic Cure for Heart Attacks

The stem cell researchers have decided to see if they could kick mature heart cells back into dividing action, rather than forming scar tissue. Using a high-volume screen, they first looked through miRNAs that can stimulate mature heart cells to divide after a heart attack in mice. Humans have up to 600 different types of these regulators floating around our cells, and they have been linked to everything from cancer and kidney problems to brain development, transgenerational inheritance—and yes—heart disease.

These cells could meet a critical clinical need. Although modern medicine has ways to reduce damage from heart attacks, surviving patients still often retain permanent damage to the heart’s structure. Unlike skin or liver cells, mature heart cells are stoic little buggers because they do not usually replenish themselves. This causes the heart to lose its ability to properly contract and pump blood, which eventually leads to heart failure. By using stem cell therapy to replace damage tissues, research has shown that this will improve the cardiac health of the patient. Research shows that pluripotent stem cell-derived cardiomyocytes can form beating human heart muscle cells that both release the necessary signals and replace muscle lost to heart attack. Transplantation of pluripotent stem cell-derived cardiac cells have demonstrated substantial benefits to cardiac function.Reference: A Closer Look at Stem Cells : Heart Disease. Retrieved from https://www.closerlookatstemcells.org/stem-cells-medicine/heart-disease/

Diabetes

Figure 2. Pictures show the same ulcer before (left) and three months (right) after therapy. The photographs demonstrate a remarkable improvement in clinical status, where amputation is avoided, hence the foot is saved.
Stem cell is only one of the few treatment modalities that can reverse or minimize the effects of diabetes. Stem Biotech will play an important part in a worldwide effort to stem the onslaught of this devastating disease.

Cancer Detection and Prevention

In preclinical research, it was found that this new strategy to produce pluripotent stem cell-derived natural killer cells can effectively kill cancer cells in cell culture and in mouse models.
The off-the-shelf, iPSC-derived natural killer (NK) cell cancer immunotherapy received U.S. Food and Drug Administration approval to move into clinical trials in November 2018. Stem cell researchers has been collaborating over the past four years to bring iPSC-derived NK cells to patients with cancer. NK cells are specialized immune cells that are very potent at killing cancer cells, while NK cells can be isolated from the blood of donors or patients, this trial uses NK cells entirely produced in the lab from human iPSCs. Since human iPSCs possess the unique dual properties of unlimited self-renewal and differentiation potential into all cell types of the body, these cells can be used as starting material to mass produce NK cells at significant scale in a cost-effective manner.

Lung & Liver Disease


Image Credit: science pics / Shutterstock.com

Living Lung Bioreactor

Researchers took a different approach in trying to directly repair lungs inside the body, they tackled another clinical problem: the lack of transplantable donor lungs. Roughly 80 percent of donor lungs are too damaged for transplantation. Although there are many sources of trauma, including injuries from ventilators or fluid buildup inside the organ, the team focused on a major cause of damage: stomach contents. Lungs are sensitive snowflakes. They are extremely easily scuffed up by stuff that comes out of our stomachs, such as food particles, bile, gastric juices, and enzymes. Usually our lungs can heal; but in the case of transplantation—right after death—they often do not have the time to self-repair. This lung shortage led researchers to look for alternative ideas which took seven years of banging their heads against a wall. Then came the winning lightbulb moment: if man-made devices are not enough to repair lungs outside the body, what about the eventual recipient? After all, lungs do not work alone—they thrive in a physiological milieu chock full of molecules that activate when the body senses injury.

The team first poured gastric acid into the lungs of an unconscious donor pig to mimic injury. After six hours, they extracted the damaged lung and placed it carefully into a warm, humidified sterile bowl—the organ chamber—and hooked the organ up to a ventilator. They then connected the lung’s blood vessels to the recipient’s circulation. This essentially uses the recipient to help break down toxic molecules in the injured lungs while supplying them with fresh nutrients and healing factors.


Credit: Brandon Guenthart/Columbia Engineering

Macroscopic appearance of lungs throughout 36 h of ex vivo support. Image Credit: Brandon Guenthart/Columbia Engineering.

It sounds pretty gruesome, but the trick worked. When supplemented with a wash that rinsed out stomach juices, the lungs regenerated in just three days. Compared to non-treated lungs, their functions improved six-fold.
References: Fan, Shelly. Singularity Hub. New Progress in Stem-Cell Free Regenerative Medicine. Retrieved from https://singularityhub.com/2019/05/23/new-progress-in-stem-cell-free-regenerative-medicine/

Cosmetic Improvements

In 2019’s current health and beauty focused climate, people are on a quest to fight the signs of aging (or prevent it altogether) and many have begun looking for alternative ways to roll back the clock. With advancements in stem cell and platelet-rich plasma (PRP) therapy, more people are ditching standard procedures like facelifts for newer, regenerative treatments to reverse aging starting at the cellular level. Even athletes are seeing the effects of stem cell therapy to heal injuries and stimulate growth factors.


Credit: CC0 Public Domain

How do stem cells work, what is stem cell therapy and how are people using it in the cosmetics field now?

First, we should distinguish the difference between adult and embryonic stem cells. Embryonic stem cells are derived from an embryo and can become all types of cells within the body. They don’t have a specific function other than to be a manufacturing plant to create other types of cells. As we develop into a child these cells become more specific, called adult stem cells or multipotent stem cells. We have many of these cells as youth, but slowly, over time, we lose them as we age. Because of this, we take longer to recover from a sports injury or a wound as quickly. Several years ago, it seemed like there was no way to turn the clock back, until now. Recent research has discovered methods in which we can turn these cells back on or take them from one part of the body and place them in another. We are currently able to take blood and prepare it in a way to concentrate the platelets and white blood cells to turn these cells on for a while to reverse or slow aging or speed up the healing cascade. There are also methods of taking your fat, which was recently discovered as a storehouse for adult stem cells, like bone marrow, where we can transfer prepared fat to other parts of the body, like the face, to slow or reverse the aging of the skin and restore lost volume.

 

Is it possible to isolate the functionality of what you want those stem cells to do? For example, using them to repair sun damage, is it possible to isolate their functions for a specific purpose in the body?

The scientific evidence being published has shown that we can take adult stem cells and cause them to form certain types of cells. For instance, adult stem cells from your fat can be grown into bone, cartilage, muscle and skin. This is all groundbreaking for the field of reconstructive surgery. For example, our cancer patients would get mastectomies and have their whole breast tissue removed and have implant reconstruction. They would just have a bag of skin over an implant, which would look unnatural as there’s really no fat and all you could see were the ripples and the deformities from the implant. Some surgeons really thought ahead and decided to take some fat from the patient and put fat where these ripples were to lessen the appearance of the deformity. They also noticed that by doing this, the patients recovered faster from the procedure.

In contrast, there were some doctors and scientists that thought they should not inject fat in the breasts of breast cancer patients because the stem cells in the fat could potentially enable breast cancer to develop again. It was kind of taboo to talk about this for a while. Fortunately, recent clinical studies have proven otherwise. What they also discovered is that with fat transfer on breast cancer patients with radiation damage, the damaged skin would also become soft and get better largely due to the stem cells found in fat. Just picture people who had radiated skin that looked like leather, and it healed. They realized there was a serious correlation between fat transfers and inadvertent repair and reproduction of healthy cells via innate stem cells in the fat.


Image Credit: science pics / Shutterstock.com

Importance of stem cells in human medicine

Stem cell therapy offers the unique ability to regenerate cells and use it to repair damaged cells in the human body. Stem cell therapies and regenerative medicine can help patients who are suffering from conditions such as type 1 diabetes, heart disease, spinal cord injuries, blood disorders to grow healthy cells and improve their overall health. In an article published by the University of Nebraska, entitled The importance of stem cells, it stated that scientists have shown that stem cells reside in most tissues of the body and research continues to learn how to identify, extract, and proliferate these cells for further use in therapy. Scientists hope to yield therapies for diseases such as type I diabetes and repair of heart muscle following heart attack. Stem cell therapy will revolutionize the approach to traditional medical treatments. University of Nebraska. The Importance of Stem Cells. Retrieved from https://www.unmc.edu/stemcells/educational-resources/importance.html

Internal Stem Cell Research

ALEXANDROS

This company specializes in the emerging stem cell research arena related to therapy, clinical study management, and FDA regulations. They have contacts in Dubai, China, Austria, and Brazil.

Management Team

Dr. Nayan Shah – CEO

Dr. Nayan Shah is one of the world’s foremost researchers in stem cell technology and has headed the Cleveland Clinic Technology Transfer for 27 years, he will head Stem Biotech market rollout. Dr. Nayan Shah who has been involved in stem cell research, technology has been monitoring development in these fields worldwide for more than 15 years including regenerative medicine.

Mannix Medical Technology – Alexandros, President

CEO, Mentor, Ohio

Mannix Medical Technology (MMT) – Alexandros is a multi-faceted medical technology management firm specializing in direct assistance to medical technologist, entrepreneurs, medical startups and universities. Dr. Shah’s effective leadership skills has brought new technologies from concept form into the marketplace and has resulted in a successful product launch. The company is placing special emphasis in the emerging stem cells area related to therapy, clinical study management and FDA regulations. The company has contracts in the following country: Austria, Brazil, China and Dubai.

Dr. Shah’s medical academic training:

  • University of London
  • St. Mary’s Hospital
  • University of Chicago
  • Kendall Corporation – Colgate-Palmolive
  • Sherwood Medical – St. Louis, MO.
  • Brunswick Corporation – Chicago
  • Desert Medical, Sandy – Utah
  • Becton-Dickinson – Morristown, NJ
  • Fasson Division of Avery International – California